# Natura Inside Premium Cannabis Oil – 7% Broad Spectrum CBD with Piperine & Coffee Oil, Dryas Series, 10ml

**CBD Coffee Drops with Piperine**  
**Natural Synergy for Daily Premium Care**

**Dryas** is crafted with CBD, cold-pressed Arabica coffee seed oil, and piperine, offering a plant-based formulation that can be easily integrated into daily routines. The blend combines full extract CBD with natural oils, designed to support a balanced lifestyle.

### Features

-   **CBD Content**: 7% (700mg per 10ml)
    
-   **With Piperine**: Included to support ingredient bioavailability
    
-   **Cold-Pressed Coffee Seed Oil**: Adds a natural touch from Arabica coffee seeds
    
-   **Plant-Based**: Made with carefully selected natural ingredients
    

🧪 **How to Use**  
• Shake well before use  
• Apply a small amount 2–3 times daily, preferably every day  
• Store in a cool, dark place at room temperature (15–25 °C)

_Want to learn more about cannabidiol & coffee oil? Check out this short blog._

* * *

### 🧬 **Cannabidiol (CBD) and Scientifically Documented Properties**

Cannabidiol (CBD) is a natural phytocannabinoid derived from the _Cannabis sativa_ plant. Unlike tetrahydrocannabinol (THC), CBD is **non-psychoactive**, making it safe for daily use¹. It interacts with the **endocannabinoid system (ECS)**, which regulates key physiological functions such as anxiety, pain, sleep, and immune balance².

* * *

📌 **Key Properties Identified in Scientific Literature:**  
• **Anxiety and stress relief**: CBD appears to interact with serotonin receptors, contributing to anxiolytic effects³. It has been studied in cases of social anxiety, generalized anxiety disorder, and PTSD.  
• **Sleep support**: Research shows that CBD may improve sleep quality and duration, particularly when sleep disturbances are related to anxiety⁴.  
• **Anti-inflammatory and analgesic properties**: CBD influences CB1, CB2, and TRPV1 receptors, supporting relief from chronic or neuropathic pain and reducing inflammation⁵.  
• **Physiological balance (homeostasis)**: By modulating the ECS, CBD may help support general wellbeing and internal balance⁶.  
• **Antioxidant and immunomodulatory effects**: Experimental data suggest CBD may reduce pro-inflammatory cytokines and support immune response⁷.

**References**

1.  World Health Organization. (2018). _Cannabidiol (CBD) Critical Review Report_.
    
2.  Lowe, H. I. C., Toyang, N. J., & McLaughlin, W. (2021). _Medicines_, 8(6), 44. [https://doi.org/10.3390/medicines8060044](https://doi.org/10.3390/molecules26237216)
    
3.  Blessing, E. M., et al. (2015). _Neurotherapeutics_, 12(4), 825–836. [https://doi.org/10.1007/s13311-015-0387-1](https://doi.org/10.1007/s13311-015-0387-1)
    
4.  Shannon, S., et al. (2019). _The Permanente Journal_, 23. [https://doi.org/10.7812/TPP/18-041](https://doi.org/10.7812/TPP/18-041)
    
5.  Whiting, P. F., et al. (2015). _JAMA_, 313(24), 2456–2473. [https://doi.org/10.1001/jama.2015.6358](https://doi.org/10.1001/jama.2015.6358)
    
6.  Nichols, J. M., & Kaplan, B. L. (2020). _Cannabis and Cannabinoid Research_, 5(1), 12–31. [https://doi.org/10.1089/can.2018.0073](https://doi.org/10.1089/can.2018.0073)
    
7.  Kozela, E., et al. (2011). _Journal of Neuroimmune Pharmacology_, 6(3), 529–540. [https://doi.org/10.1111/j.1476-5381.2011.01379.x](https://doi.org/10.1111/j.1476-5381.2011.01379.x)
    
8.  Stahl, V., & Vasudevan, K. (2020). _Cureus_, 12(1), e6809. [https://doi.org/10.7759/cureus.6809](https://doi.org/10.7759/cureus.6809)
    
9.  Iffland, K., & Grotenhermen, F. (2017). _Cannabis and Cannabinoid Research_, 2(1), 139–154. [https://doi.org/10.1089/can.2016.0034](https://doi.org/10.1089/can.2016.0034)
    
10.  Regulation (EU) No 1307/2013 and Directive 2002/46/EC – **EU compliance on hemp and novel foods**
     

### ☕ Coffee Oil: A Multifunctional Bioactive for Skin Health and Inner Balance

Coffee oil, obtained through the cold pressing of green or roasted coffee beans, is a **bioactive-rich extract** containing **diterpenes (cafestol, kahweol), tocopherols (vitamin E), phytosterols, and polyphenols**. These compounds offer **dual benefits** for both **topical (skin care)** and **systemic (nutritional)** applications. When used on the skin, coffee oil exhibits **antioxidant, anti-inflammatory, and revitalizing** properties—helping to **protect against oxidative stress**, **improve elasticity**, and **support the skin barrier**. Its **essential fatty acids** contribute to **hydration and smoothness**, while **caffeine and diterpenes** help **stimulate microcirculation**, enhancing skin tone and radiance (Dourado et al., 2020; Herman & Herman, 2013).

When taken as a supplement, the same bioactive molecules act internally to **protect cells from oxidative damage**, **support liver detoxification**, and **promote lipid balance**. Diterpenes such as **cafestol and kahweol** activate **phase II detoxifying enzymes** and **glutathione synthesis**, reinforcing liver function (Cavin et al., 2002). Meanwhile, **phytosterols** like **β-sitosterol** and **stigmasterol** assist in **cholesterol regulation** and cardiovascular support (Godos et al., 2014). Overall, coffee oil represents a **synergistic botanical ingredient** that supports **skin vitality, cellular protection, and systemic well-being**, bridging the connection between **outer beauty and inner health**.

**References:**

-   Cavin, C., Holzhaeuser, D., Scharf, G., Constable, A., Huber, W. W., & Schilter, B. (2002). Cafestol and kahweol, two coffee-specific diterpenes with anticarcinogenic activity. _Food and Chemical Toxicology, 40_(8), 1155–1163.
    
-   Dourado, G. K. Z. S., de Souza, A. L. R., & dos Santos, P. O. (2020). Coffee oil as an ingredient in cosmetics: A review. _Journal of Cosmetic Dermatology, 19_(9), 2407–2414.
    
-   Godos, J., Pluchinotta, F. R., Marventano, S., Buscemi, S., Li Volti, G., Galvano, F., & Grosso, G. (2014). Coffee components and cardiovascular risk: Beneficial and detrimental effects. _Public Health Nutrition, 17_(9), 2073–2089.
    
-   Herman, A., & Herman, A. P. (2013). Caffeine’s mechanisms of action and its cosmetic use. _Skin Pharmacology and Physiology, 26_(1), 8–14.
    

**Note:** This product is registered in the European CPNP database with **Notification Number: CPNP 4619441**.

The information presented is based on published scientific literature regarding **the compounds** and **does not constitute a health claim** for the final product. This product is **not intended to diagnose, treat, cure, or prevent any disease**.

## Details

- **Price:** 12.99 EUR
- **Vendor:** Natura Inside
- **Type:** CBD OIL
- **Tags:** ANTISTRESS, CANNABINOIDS, CANNABIS, CBD, CBD FOR PETS, COFFEE, COFFEE OIL, CONCENTRATION, FOCUS, HEALTH, HEMP, NATURAL, NEUROPROTECTION, PETS, RELAX, SLEEP, STRESS, WELLBEING, WELLNESS

## Variants

| Variant | Price | Available |
|---------|-------|-----------|
| Default Title | 12.99 EUR | In stock |

## Images

- CBD drops dropper bottle with coffee extract, shown with product box and label
- Certificate of Analysis document with cannabinoid test table and signature
- Certificate of analysis document for hemp oil, lists metals detection values

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> Source: [NATURA INSIDE WELLNESS](https://naturainside.com/products/natura-inside-premium-cannabis-oil-7-broad-spectrum-cbd-with-piperine-coffee-oil-dryas-series-10ml-copy)
> Updated: 2026-08-29